Process for the purification of gabapentin

Details Process for the purification of gabapentin Process for the purification of gabapentin

2011-08-02

2011-08-02

Sullivan, Daniel (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

Reexamination Certificate

active

07989658

ABSTRACT:
The present invention relates to a process for the purification of gabapentin. The process relates to the addition of hydrochloric acid to an aqueous solution or suspension of gabapentin, before, during or after the concentration step of that solution, and the subsequent slurry of the gabapentin by the addition of an alcoholic solvent. The so obtained gabapentin has an high purity degree and, in particular, is characterized by a low content of lactam.

REFERENCES:
patent: 6518456 (2003-02-01), Peverali et al.
patent: 2004/0063997 (2004-04-01), Ferrari et al.
patent: 2004/0068011 (2004-04-01), Cannata et al.
patent: 2007/0123590 (2007-05-01), Giovanetti et al.
patent: 2007/0129569 (2007-06-01), Cotarca et al.
patent: 2004 093779 (2004-11-01), None

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