Process for the purification of cyclosporin A

Details Process for the purification of cyclosporin A Process for the purification of cyclosporin A

1993-05-25

1995-01-17

Lee, Lester L.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Cyclic peptides

530323, A61K 3702, C07K 750, C07C10352

Patent

active

053826558

ABSTRACT:
A process is disclosed for the solution chromatographic purification of cyclosporin A from a starting mixture containing one or more of cyclosporin A, B, C, other cyclosporin components that are more polar or more apolar than cyclosporin A, and other like contaminants, by heating the starting mixture or an evaporation residue thereof to a temperature from about 80.degree. C. to about 115.degree. C., melting the heated starting mixture, and carrying out solution chromatography of the melted material, suitably first in a 48:50:2 mixture of chloroform, dichloromethane, and ethanol, and then in a mixture of like proportions, of the solvents chloroform, ethylacetate, and ethanol.

REFERENCES:
patent: 4117118 (1978-09-01), Harri et al.
patent: 4215199 (1980-07-01), Harri et al.
patent: 4554351 (1985-11-01), Wenger
patent: 5116816 (1992-05-01), Dreyfuss et al.

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