Process for the purification of clavulanic acid

Details Process for the purification of clavulanic acid Process for the purification of clavulanic acid

1976-12-16

1979-03-13

Rush, Raymond V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

195 36P, 195 80R, 546198, 424115, 424271, 424272, C07D49804

Patent

active

041442423

ABSTRACT:
The invention provides the compound (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0]-heptane -2-carboxylic acid and its salts in purified form and pharmaceutical compositions containing them and a process for the purification of such compounds by conversion in aqueous media to the lithium salt of the above acid and precipitation thereof.

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