Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1989-02-10
1992-03-31
Moskowitz, Margaret
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530395, 530806, 530416, 530412, 530417, 530413, C07K 1504, C07K 1514, C07K 318, C07K 328
Patent
active
051010143
ABSTRACT:
The present invention comprises a method for the purification of the 69 kDa outer membrane protein of Bordetella B. pertussis and the protein purified therewith. A preferred embodiment comprises the purification of the 69 kDa protein from Bordetella B. pertussis strain Bp 353. The present process is advantageous in that it does not require or involve the use of biologics (such as monoclonal antibodies) and therefore simplifies the purification procedure and makes the resulting purified protein particularly advantageous for inclusion in acellular vaccines.
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Brennan Michael J.
Burns Drusilla L.
Gould-Kostka Jeanine L.
Manclark Charles R.
Furman Keith C.
Moskowitz Margaret
United States of America
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