Process for the purification of 2-[(dimethylamino)methyl]-1-(3-m

Details Process for the purification of 2-[(dimethylamino)methyl]-1-(3-m Process for the purification of 2-[(dimethylamino)methyl]-1-(3-m

1993-09-08

1995-05-09

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564438, 564443, C07C20984, C07C20986, C07C20988

Patent

active

054141290

ABSTRACT:
A process for the improved purification and separation of trans 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride from a reaction mixture containing the trans isomer, the cis isomer and Grignard reaction side products, comprising combining the mixture with a solution of hydrochloric acid in a low molecular weight alcohol or with gaseous hydrogen chloride in the presence of an organic solvent selected from medium molecular weight alcohols, ketones, esters and ethers or aromatic ethers, to effect the selective precipitation of trans 2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexanol hydrochloride.

REFERENCES:
patent: 3452011 (1969-06-01), Skaletzky
patent: 3652589 (1972-03-01), Flick et al.
patent: 3830934 (1974-08-01), Flick et al.
Flick et al., Arzneim-Forsch., 28(1A), 107-13 (1978).
Frankus et al., Arzneim.-Forsch., 28(1A, 114-21 (1978).
Eiden et al., Arch. Pharm., vol. 320(11), pp.1099-1103 (1987).
Shirai et al., Nagoya Shiritsu Daigaku Kenkyu Nempo, vol. 21, pp. 18-21 (1973).
Yashiro et al., Chem. Pharm. Bull, vol. 23(9), pp. 2054-2057 (1975).

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