Process for the production of xylazine

Details Process for the production of xylazine Process for the production of xylazine

1985-04-09

1986-09-30

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

558 18, C07D27904, C07C16102

Patent

active

046147985

ABSTRACT:
In the preparation of 2,6-dimethylphenylisothiocyanate by reacting N-(2,6-dimethylphenyl)acetamide with sodium hydride in an organic solvent to form the corresponding anion of said amide, then reacting carbon disulfide with said anion to form said 2,6-dimethylphenylisothiocyanate, unexpectedly high yields are obtained by using as the organic solvent tetrahydrofuran or a mixture of N,N-dimethylacetamide and toluene. 2,6-Dimethylphenylisothiocyanate is an intermediate in the preparation of xylazine useful, for instance, as a sedative, an analgesic and muscle relaxant.

REFERENCES:
patent: 3235550 (1966-02-01), Behner et al.
Shahak et al., J. Am. Chem. Soc., 95, 3440 (1973).
Jen et al., J. Med. Chem., 18, 99 (1975).

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