Process for the production of virus vaccine

Details Process for the production of virus vaccine Process for the production of virus vaccine

1982-01-04

1987-04-21

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Lymphokine

435236, 435238, 424 86, 530387, 530404, 530406, 530413, 530806, 530825, A61K 3912, A61K 39145, A61K 39165, A61K 3917

Patent

active

046595694

ABSTRACT:
The present invention relates to a process for the production of virus vaccine, comprising covalently attaching virus to saccharide to form a virus-saccharide conjugate, and harvesting the resultant conjugate. The virus vaccine, prepared according to the present invention, exhibits a higher producibility of immunoglobulin G and immunoglobulin M antibodies, while it induces less or substantially no production of immunoglobulin E antibody, in comparison with conventional-type inactivated virus vaccine; thus, the present vaccine is favorably usable for the prevention and treatment of viral diseases.

REFERENCES:
patent: 4003792 (1977-01-01), Mill et al.
patent: 4372883 (1983-02-01), Matuhashi et al.
Veith et al., "Enzyme Engineering", Chemtech, Jan. 1974, pp. 47-55.
The American Type Culture Collection, Catalogue of Strains II, Second Edition, 1979, pp. 148, 168, and 169.
Fielder et al., J. Immun., vol. 105, No. 1, pp. 265-267 (1979).
Schneerson et al., J. Exp. Med., vol. 152, pp. 361-376 (1980).

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