Process for the production of vaccine

Details Process for the production of vaccine Process for the production of vaccine

1980-08-18

1983-02-08

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260112B, 424 88, 428 89, 424 90, 424 91, 424 92, 424 85, 424 86, 424 87, 435 7, 536 5, 536 41, 436543, A61K 39385, C07G 700

Patent

active

043728839

ABSTRACT:
The present invention relates to a process for the production of vaccine, characterized by covalent attachment of a biologically toxic substance to a saccharide both to form a biologically toxic substance-saccharide conjugate and to detoxify said substance, followed by collection of the formed conjugate. According to the invention, various vaccine products having a high productivity of immunoglobulin G and M antibodies, but without productivity of immunoglobulin E antibody, are easily obtainable. In addition, the vaccine products, upon administration to animals, do not effect any allergic reaction and/or anaphylactic-shock due to the lack of the immunoglobulin E antibody production.

REFERENCES:
patent: 3641235 (1972-02-01), Weiss
patent: 3645852 (1972-02-01), Axen et al.
patent: 4003792 (1977-01-01), Mill et al.
patent: 4046722 (1977-09-01), Rowland
patent: 4057685 (1977-11-01), McIntire
patent: 4093607 (1978-06-01), Sela et al.
patent: 4125492 (1978-11-01), Cuatrecasas et al.
patent: 4140679 (1979-02-01), Malley
patent: 4226978 (1980-10-01), Boguslaski et al.

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