Process for the production of urokinase in pure condition

Details Process for the production of urokinase in pure condition Process for the production of urokinase in pure condition

1979-06-29

1981-03-31

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435815, C12N 972

Patent

active

042594472

ABSTRACT:
There is provided a process for the production of pure, concentrated urokinase starting from a crude urokinase solution. The crude urokinase solution is contacted in a medium having a pH of .gtoreq.6 with a porous solid matrix having a high specific surface area on whose surface there is immobilized aprotinin. Subsequently the urokinase adsorbed in this manner is eluted in an elution agent having a pH.ltoreq.4.5. There are obtained highly concentrated and very pure solutions of urokinase. The urokinase is used in medicine as a pharmaceutical for the dissolving of fibrinous clots and coagulums.

REFERENCES:
patent: 3010074 (1977-03-01), Uemura et al.
patent: 4066506 (1978-01-01), Johnson et al.
patent: 4165258 (1979-08-01), Pye
Johnson et al., Analytical Biochemistry, vol. 72, pp. 573-576 (1976).
Chemical Abstracts, vol. 87, refernce 196465u (1977).
Chemical Abstracts, vol. 85, reference 173512b (1976).
Chemical Abstracts, vol. 85, reference 16039k (1976).

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