Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1989-03-03
1991-07-23
Rivers, Diana
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
544319, C07F 96512
Patent
active
050345290
ABSTRACT:
In a process for the production of a thiophosphoric acid ester of formula I ##STR1## wherein R.sub.1 is lower alkyl, lower alkenyl, lower alkoxy(lower)alkyl or lower alkylmercapto(lower)alkyl, R.sub.2 is hydrogen, lower alkyl or lower alkenyl and R.sub.3 and R.sub.4 are lower alkyl, which comprises reacting a dialkyl phosphoric acid halide of formula II ##STR2## wherein Hal is chlorine or bromine and R.sub.3 and R.sub.4 are as defined hereinabove, with a hydroxypyrimidine of formula III ##STR3## wherein R.sub.1 and R.sub.2 have the significance given to them above, at elevated temperatures and in the presence of an organic solvent and an acid-binding agent, the improvement which comprises adding the reactant of formula II to an essentially dry mixture of the hydroxypyrimidine of formula III and the acid-binding agent in the presence of a low molecular weight water-insoluble aliphatic or cycloaliphatic ketone as organic solvent after removing the water of reaction from said mixture.
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Research Disclosure, 310114 (Feb., 1990).
Ciba-Geigy Corporation
Mansfield Kevin T.
McC. Roberts Edward
Rivers Diana
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