Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1980-06-20
1982-04-20
Daus, Donald G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C07F 965
Patent
active
043260594
ABSTRACT:
An improved process for the production of dialkoxy phosphoric acid esters of substituted hydroxypyrimidines which involves reacting a dialkyl phosphoric acid halide with a substituted hydroxypyrimidine reaction in a two-step reaction is disclosed. In reaction step (a) the hydroxypyrimidine derivative is converted with the aid of sodium hydroxide and in the presence of a hydrocarbon solvent and a phase-transfer catalyst to the sodium salt while drying the reaction mixture by azeotropically removing water. In step (b) the condensation process is carried out at room temperature to about 100.degree. C. The condensation step may be accelerated by addition of 4-bis(C.sub.1 to C.sub.4 alkyl)aminopyridine as catalyst.
REFERENCES:
patent: 3657247 (1972-04-01), Freeman et al.
patent: 4007197 (1977-02-01), Freedman et al.
patent: 4012506 (1977-03-01), Balke et al.
Gargano Robert
Perez Donald E.
Williams David K.
Ciba-Geigy Corporation
Daus Donald G.
Jorda Karl F.
Rivers Diana G.
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