Process for the production of thiophosphoric acid esters

Details Process for the production of thiophosphoric acid esters Process for the production of thiophosphoric acid esters

1976-04-19

1978-01-03

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07F 965

Patent

active

040666425

ABSTRACT:
An improved process for the production of dialkoxy phosphoric acid esters of substituted hydroxypyrimidines which involves reacting a dialkyl phosphoric acid halide with a substituted hydroxypyrimidine at elevated temperatures and in the presence of an inert non-polar organic solvent and an acid binding agent but without catalyst, wherein the phosphoric acid halide and sodium or potassium hydroxide in molar excess of about 5 to 10% are added to a reaction mixture in reflux consisting essentially of the hydroxypyrimidine in molar excess of about 1 to 5% and the non-polar solvent at uniform rates over a period of 1 to 7 hours while removing water substantially as it is formed thereby impeding formation of cholinesterase inhibiting impurities. A preferred embodiment is the preparation of Diazinon.

REFERENCES:
patent: 2754243 (1956-07-01), Gysin et al.
patent: 3004054 (1961-10-01), Smithey, Jr.
patent: 3107246 (1963-10-01), Ferguson
patent: 3329678 (1967-07-01), Curry et al.
patent: 3432503 (1969-11-01), Ferguson
patent: 3741968 (1973-06-01), Haubein

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