Process for the production of the isomers (R) and (S)-.alpha.-me

Details Process for the production of the isomers (R) and (S)-.alpha.-me Process for the production of the isomers (R) and (S)-.alpha.-me

1997-07-31

1998-09-15

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564304, C07C20928, C07C20988

Patent

active

058081569

ABSTRACT:
Process for the production of the isomers (R) and (S)-.alpha.-methyl-3-(trifluoromethyl)benzeneethanamine, the second being useful as intermediate in the synthesis of the anorexic drug dexfenfluramine (INN), which comprises carrying out a stereospecific reductive amination of 1-(3-trifluoromethyl)phenyl-2-propanone with (R) or (S)-.alpha.-methylbenzylamine under a hydrogen atmosphere in the presence of a catalyst and debenzylating the resulting diastereoisomer (R),(R) or (S),(S)-N-(1-phenylethyl)-.alpha.-methyl-3-(trifluoromethyl)benzeneethanam ine by treatment with hydrogen and a catalyst.

REFERENCES:
patent: 3198833 (1965-08-01), Beregi et al.
Abstract 74597W/45 of GB 1413-070, Nov. 1975.
Jacewicz, Chemical Abstracts, vol. 84, abstract 30637, 1976.
Jacewicz, Chemical Abstracts, vol. 84, abstract 30636, 1976.

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