Process for the production of the calcium salt of pantothenic ac

Details Process for the production of the calcium salt of pantothenic ac Process for the production of the calcium salt of pantothenic ac

1974-09-06

1976-01-27

Raymond, Richard L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260534C, C07C 9904, C07C 9910

Patent

active

039352560

ABSTRACT:
An improved process for the preparation of dl-calcium pantothenate is described wherein an anhydrous calcium salt of B-Alanine in methanolic solution is reacted with dl-pantolactone directly in a one-step process. The salt of B-Alanine is prepared by reacting acrylonitrile with ammonia, the B-amino-propionitrile formed is hydrolyzed in 50% sodium hydroxide and the sodium salt reacted with a solution of calcium chloride in a liquid which will form an azeotropic mixture with water, any excess sodium hydroxide is neutralized with hydrochloric acid and the water removed by an azeotropic distillation. The reaction mixture is then taken up in methanol and reacted with the dl-pantolactone directly.

REFERENCES:
patent: 2809213 (1957-10-01), Lekberg et al.
patent: 3564052 (1971-02-01), Freed

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