Process for the production of tert-butyl...

Details Process for the production of tert-butyl... Process for the production of tert-butyl...

2005-05-24

2008-10-07

Zucker, Paul A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

Reexamination Certificate

active

07432391

ABSTRACT:
The present invention is to provide a safe process for the production of tert-butyl N-(2-bromoethyl)carbamate where operation is simple, handling of the final product is easy, working efficiency is good and yield is high.A process for the production of tert-butyl N-(2-bromoethyl)carbamate, characterized in that, 2-bromoethylamine or a salt thereof is made to react with an agent for introducing a tert-butoxy carbonyl group in a water-soluble solvent in the presence of sodium hydroxide and then water as a crystallizing solvent and seed crystals are added to the reaction solution whereby crystals of tert-butyl N-(2-bromoethyl)carbamate are separated out therefrom.

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Vedejs et al, Journal of Organic Chemistry, Synthesis of Azocine Derivatives from Thioaldehyde Diels-Alder Adducts, 1988, 53, pp. 2226-2232.
V. G. Beylin et al. “A Convenient Synthesis of t-butly N-(2-bromoethyl)carbamate”, OPPI Briefs, vol. 19, No. 1, pp. 78-81 (1987).

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