Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2005-01-18
2005-01-18
Ford, John M. (Department: 1624)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C544S243000, C544S229000
Reexamination Certificate
active
06844437
ABSTRACT:
The invention concerns a process for the manufacture of tert-butyl (E)-(6-[2-4-(4-flourophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl]vinyl)-(4R,6S)-2,2-dimethyl[1,3]-dioxan-4-yl)acetate, the novel starting material used in said process and the use of the process in the manufacture of a pharmaceutical.
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patent: WO 97 19917 (1997-06-01), None
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Watanable et al., “Synthesis and biological activity of methanesulfonamide pyrimidine-and N-methanesulfonyl pyrrole-substituted 3,5-dihydroxy-6-heptenoates, a novel series of HMG Co-A reductase inhibitors”, Bioord. Med. Chem., vol. 5, No. 2, 1997, p. 437-444.
T. Hiyama et al.: “Synthesis of Artificial HMG-CoA Reductase Inhibitors Based on the Olefination Strategy” Bull. Chem. Soc. JPN., vol. 68, No. 1, 1995, pp. 364-372, XP000888402 *Scheme 3* table 1.
Diorazio Loius J
Kabaki Mikio
Koike Haruo
Taylor Nigel P
Astrazeneca AB
Ford John M.
Morgan & Lewis & Bockius, LLP
Shionogi & Co. Ltd.
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