Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1985-07-05
1988-12-27
Brown, J. R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 184, 536 185, 536124, 260408, 260694, C07H 100, C07B 3900
Patent
active
047941782
ABSTRACT:
Organic compounds labeled with no-carrier-added fluorine 18 are processed yield a compound having a formula in the form of .sup.18 F-R through a nucleophilic substitution reaction. The process has a series of steps. The first step of the process relates to providing an organic compound having a formula of X-R. X is the nucleophilic leaving group in the substitution action, and R is a preferred substituted hydrocarbon structure being selected from aliphatic, alicyclic, heterocyclic aliphatic, carbocyclic and heterocyclic aromatic structures. The X-R compounds with acid hydrogen are excluded. The next step is to bring the organic compound X-R into contact with fluoride ions which are present in a solvent. These fluoride ions are essentially carrier free .sup.18 F ions. The organic compound is brought into contact with the fluoride ions in an apparatus to produce a reaction. The reacting mixture comes into contact during reaction only with surfaces in the apparatus which are made of metals as copper, stainless steel, platinum and Inconel and preferably of glassy carbon. In one embodiment, the reaction takes place at a temperature of between 100.degree. C. and 150.degree. C. in the presence of a basic alkali salt which is contained in a acetamide melt. The reaction may alternately take place in a preferred embodiment, in solution, in a moderately polar, aprotic solvent in the presence of a macrocyclic polyether and an alkali salt at a temperature in the range of 50.degree. C. to 150.degree. C.
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Coenen Heinrich H.
Hamacher Kurt
Klatte Bernd
Knochel Arndt
Schuller Manfred
Brown J. R.
Kernforschungsanlage Julich Gesellschaft mit beschrankter Haftun
Ljungman Nils H.
Peselev Elli
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