Process for the production of substituted nicotinic acid esters

Details Process for the production of substituted nicotinic acid esters Process for the production of substituted nicotinic acid esters

2004-03-05

2009-02-10

Andres, Janet L (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C546S268700, C546S315000, C546S282400, C546S280400, C546S276100, C546S268100, C546S272100, C546S284400, C546S282100, C560S183000

Reexamination Certificate

active

07488824

ABSTRACT:
The present invention relates to a process for the preparation of compounds of formula (I) wherein the substituents are as defined in claim1, by reaction of a compound of formula (II) wherein R3is C1-C8alkyl or C3-C6cycloalkyl and R4and R05are as defined for formula (I), with a compound of formula (III) wherein R, R1, R2and X1, are as defined for formula (I) in claim1, in an inert solvent in the presence of a proton source.

REFERENCES:
patent: 1340747 (2003-09-01), None
patent: 2001158774 (2001-06-01), None
patent: WO 0039094 (2000-07-01), None
patent: WO 0194339 (2001-12-01), None
Bottorff, E.M.; Jones R.G., Kornfeld, E C; Mann M J: “Pyridine Syntheses I Some Reactions of “Ene Amines” with 1,3,-dicarbonyl derivatives” Journal of the American Chemical Society, vol. 73, 1951, pp. 4380-4383, XP002286147 (last reaction on p. 4383).

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