Process for the production of stable liquid form of beta-blocker

Details Process for the production of stable liquid form of beta-blocker Process for the production of stable liquid form of beta-blocker

1993-10-14

1996-01-16

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 58, 514 59, 514782, 514965, A61K 908, A61K 3140, A61K 4726, A61K 31135

Patent

active

054847761

ABSTRACT:
This invention relates to a process for the production of optimally stable orally administrable solution forms of medicaments containing high-molecular polysaccharides, with controlled release of drugs having beta-blocking action, this process consisting of the reacting of 1 to 20 parts (w/w) of beta-blocking agent (oxprenolol, pindolol, sotalol, metoprolol, alprenolol, acebutolol, atenolol, bopindolol, practolol, nadolol or propranolol) in 100 parts of an aqueous solution with 0.001 to 10.0 parts of a polysaccharide polymer, advantageously with Xanthan Gum having beta-1,4-glucan chain, or dextran, or amylodextrin, or carboxymethylamylum. The reaction is allowed to take place in the course of 20 minutes at a pH adjusted no 2.0-4.5, with vigorous stirring at 80.degree. C. temperature. Following the usual method of the pharmaceutical practice, the system is then formulated by the addition of water to obtain a solution suitable for oral administration.

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