Process for the production of specific isomer mixtures from oxin

Details Process for the production of specific isomer mixtures from oxin Process for the production of specific isomer mixtures from oxin

1996-10-04

1998-03-03

Higel, Floyd D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548407, 548409, 548410, 548411, 546 47, 546 48, 546 49, 546 50, C07D20954, C07D20996, C07D47100, C07D49100, C07D49800, C07D51300

Patent

active

057236259

ABSTRACT:
To produce defined isomer mixtures of compounds with spirocyclic beta-aminocarboxyl and/or beta-aminocarbonyl systems the invention supposes that they be dissolved in solvents which have good dissolving power for these compounds, whose relative permittivity is sufficient to stabilize the amphoteric intermediates occuring in isomerization, which as proton donors constitute hydrogen bridges, whose basicity is less than that of the compounds for isomerization and whose boiling point is so high that an adequate reaction speed can be attained by raising temperature. Further, the invention proposes that the isomerization be prevented, influenced, or terminated by altering at least one of these factors and or by altering the temperature.

REFERENCES:
Chemistry of Natural Compounds, vol. 12, No. 3, pp. 355-356, M.R. Sharipov et al., "Alkaloids of Vinca erecta" (New York 1976).
Chemistry of Natural Compounds, vol. 12, No. 2, pp. 201-202, M.R. Yagudaev et al., "Structure of Herboxine" (New York 1976).
Anales de Quimica, Ser. C, vol. 78, No. 2, pp. 180-183, J. Borges Del Castillo et al., "Flora salvadorena. V. Estudio de los alcaloides de la hamelia patens jaco" (Madrid, Spain 1982).
Phytochemistry, vol. 14, No. 2, pp. 565-568, F. Titeux et al., "Structure des caboxines: Alcaloides oxindoliques du Cabucala fasciculata" (France 1975).
Tetrahedron, vol. 34, No. 22, pp. 3341-3344, P.L. Majumder et al., "Stereochemistry and relative stability of the oxindoles derived from venenatine and alstovenine. The two C-3 epimeric 9-methoxy-D/E-cis-yohimbinoid alkaloids of Alstonia venenata R.Br." (Great Britian 1978).
J. Chromatogr., vol. 662, No. 2, pp. 243-249, G. Laus, D. Keplinger, "Separation of stereoisomeric oxindole alkaloids from Uncaria tomentosa by high performance liquid chromatography" (Austria 1994).
Bulletin de la Societe Chimique de France, No. 8, pp. 2766-2779, J.L. Pousset, J. Poisson, "Determination de la stereochimie des alcaloides oxindoliques" (France 1967).
Aust. J. Chem., No. 21, pp. 491-504, A.F. Beecham et al., "The Stereochemistry of Oxindole Alkaloids: Uncarines A, B (Formosanine), C (Pteropodine), D (Speciophylline), E (Isopteropodine), and F" (Austrialia 1968).
Phytochemistry, vol. 12, pp. 2795-2798, J. David Phillipson, Sarah R. Hemingway, "Oxindole Alkaloids From Uncaria macrophylla" (England 1973).
Lloydia, vol. 41, No. 6, pp. 503-570, J. D. Phillipson, S.R. Hemingway, "Alkaloids of Uncaria. Part V. Their Occurrence and Chemotaxonomy" (United Kingdom 1978).

Affiliated with

Also associated with

Rating

Process for the production of specific isomer mixtures from oxin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of specific isomer mixtures from oxin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of specific isomer mixtures from oxin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2249298