Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-06-22
1992-07-07
Fan, Jane T.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D30762
Patent
active
051284871
ABSTRACT:
In the process described for the production of sodium or potassium L-ascorbate, 2-keto-L-gulonic acid monhydrate is esterified with methanol. The esterification is only partial, that is, is not carried out until the esterification equilibrium is reached. In an intermediate step, by addition of sodium or potassium bicarbonate in an amount precisely enough for neutralizing the esterified solution, unesterified 2-keto-L-gulonic acid and impurities present are precipitated and separated out. Then by adding more bicarbonate, the lactonizing of the 2-keto-L-gulonic acid methyl ester formed is made possible. In order to reach a high yield, the unesterified 2-keto-L-gulonic acid from the bicarbonate precipitation may be re-esterified by the same process, preferably parallel, and also converted into ascorbate. This process makes possible the production of very pure sodium or potassium ascorbate, suitable for pharmaceutical purposes in a profitable way.
REFERENCES:
patent: 2179978 (1939-11-01), Elger
patent: 2462251 (1949-02-01), Bassford et al.
patent: 4180511 (1979-12-01), Crawford
Christoph Klein
Tomislav Keglevic
Enco Engineering Chur AG
Fan Jane T.
Owens Amelia A.
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