Process for the production of R(-)-4-halo-3-hydroxybutyronitrile

Details Process for the production of R(-)-4-halo-3-hydroxybutyronitrile Process for the production of R(-)-4-halo-3-hydroxybutyronitrile

1992-02-03

1993-05-11

Naff, David M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing nitrogen-containing organic compound

435843, 435844, 435845, 435846, 435822, 4352521, 435195, 435 41, 435155, C12P 1300, C12P 100, C12P 702, C12N 1914

Patent

active

052100316

ABSTRACT:
A process for the production of a 4-halo-3-hydroxybutyronitrile which comprises reacting an epihalohydrin with a halohydrin-halide-lyase originating from a microorganism selected from the group consisting of: Corynebacterium sp. N-2354 FERM BP-2726 and Microbacterium sp. N-4701 FERM BP-2644 in the presence of an alkali cyanide to thereby convert the epihalohydrin into the 4-halo-3-hydroxybutyronitrile and collecting the product thus formed is disclosed. According to this process, a 4-halo-3-hydroxybutyronitrile which is highly useful in the syntheses of various medicines and physiologically active substances can be easily and efficiently produced from an inexpensive starting material.

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