Process for the production of quinazolines

Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system

Reexamination Certificate

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C544S224000, C544S242000

Reexamination Certificate

active

07026479

ABSTRACT:
The invention provides a process for the production of a compound of formula (A), or a pharmaceutically acceptable salt or solvate thereof,wherein R1, R2, R3, and R4are as defined herein.

REFERENCES:
patent: WO98/30562 (1998-07-01), None
Seijas et al., “Microwave enhanced synthesis of 4-aminoquinazolines”, Tetrahedron Letters 41, (2000) 2215-2217.
Seijas, J. A., et al., Tetrahedron Letters, vol. 41, pp. 2215-2217, 2000, “Microwave Enhanced Synthesis of 4-Aminoquinazolines”.
Bailey, D. M., et al., Journal of Medicinal Chemistry, vol. 16, No. 2, pp. 151-156, 1973, “Hydroxyguanidines. A New Class of Antihypertensive Agents”.

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