Process for the production of prenyl diphosphate using mutants o

Details Process for the production of prenyl diphosphate using mutants o Process for the production of prenyl diphosphate using mutants o

1998-04-01

1999-03-23

Wax, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

435 41, 435193, 4352523, 435440, 536 232, C12P 700, C12N 910, C12N 1500, C07H 2104

Patent

active

058858105

ABSTRACT:
The present invention discloses a mutated enzyme comprising a geranylgeranil diphosphate synthase having its origin in wild type Sulfolobus acidocaldarius wherein at least one of phenylalanine at position 77, methionine at position 85, valine at position 99, tyrosine at position 101, phenylalanine at position 118, arginine at position 199 and aspartic acid at position 312 is substituted with another amino acid.

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Koyama, et al., Biochemistry, 33:42, pp. 12644-12648, 1994.
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Math, et al., Proc. Natl. Acad. Sci. USA, 89:6761-6764, Aug. 1992.
Ohnuma, et al., J. Biol. Chem., 269:20, pp. 14792-14797, May 20, 1994.
P.F. Marrero et al., J. Biol. Chem., 267:30, pp. 21873-21878, 1992.
Ohnuma et al. (Apil 26, 1996) vol. 271, pp. 10087-10095.

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