Stock material or miscellaneous articles – Coated or structually defined flake – particle – cell – strand,... – Particulate matter
Patent
1981-12-14
1985-11-12
Lovering, Richard D.
Stock material or miscellaneous articles
Coated or structually defined flake, particle, cell, strand,...
Particulate matter
260513B, 424 33, 424 85, 424 88, 424 94, 435 7, 435180, 436177, 436501, 436547, 42721334, 42840224, 523223, 524457, 525 541, 526315, 526909, B32B 516, C08F 1634, B01J 1302, C12N 1108
Patent
active
045528128
ABSTRACT:
Suspension polymerization of acrolein type compounds in the presence of appropriate surfactants results in the formation of microspheres in size ranging from 0.03.mu. to 80.mu.. Fluorescent and magnetic microspheres are obtained by carrying out the same polymerization in the presence of appropriate fluorochromic or ferrofluidic compounds, respectively. Hybrido polyacrolein microspheres are obtained by grafting one type of such microspheres on another type. Immunomicrospheres were formed by binding covalently at physiological pH appropriate proteins to the microspheres. The immunomicrospheres can be used for various biological applications, such as specific markers for labelling cell surface receptors, for cell separation, for diagnostic purposes, etc.
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patent: 4413070 (1983-11-01), Rembaum
Margel et al.: "Polyacrolein Microspheres as a New Tool in Cell Biology", J. Cell Science, vol. 56, pp. 157-175 (1982).
Kronick et al., "Magnetic Microspheres Prepared by Redox Polymerization . . . ", Science, vol. 200, Jun. 2, 1978, pp. 1074-1076.
Ryder, Jr. et al.: "Polymerization of Acrolein by Redox Initiation", Journal of Polymer Science: Part A, vol. 3, pp. 3459-3469 (1965).
Pourfarzaneh et al.: "Composite Polyacrolein-Coated Cellulose Magnetizable Particles . . . ", Clinica Chimica Acta III:61-63 (Mar. 1981).
Beitler Uzi
Margel Shlomo
Lovering Richard D.
White John P.
Yeda Research and Development Company
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