Process for the production of piperidine derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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10829803

ABSTRACT:
The present invention relates to processes for preparing certain piperidine derivatives, including fexofenadine (F), the active ingredient in the non-sedating antihistamine sold in the U.S. under the designation “Allegra®”. This invention also relates to novel synthetic intermediates useful in the processes of the present invention.

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Bounaim et al, Ab Initio structural study and QSAR of certain Ibuprofen derivatives as possible antlinflamotory agents, Floia Chimica Theoretica Latina; (2000); 28(1-4); pp. 88-89.
Graul, A. et al., Faxofenadine Hydrochloride, Drugs of the Future, 1996, vol. 21, No. 10, pp. 1017-1021.
Hester, Jackson, B. et al., N-[(uomega-Amino-1-hydroxyalkyl)phenyl]methanesulfonamide Derivatives with Class III Antiarrhythmic Activity, J. Med. Chem., 1991, vol. 34, No. 1, pp. 308-315.
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