Process for the production of piperazinylpyrimidine derivatives

Details Process for the production of piperazinylpyrimidine derivatives Process for the production of piperazinylpyrimidine derivatives

1991-12-06

1993-04-20

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C07D40304

Patent

active

052044653

ABSTRACT:
A process for the production of piperazinylpyrimidine derivatives of the formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and each is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, branched or unbranched. These piperazinylpyrimidine derivatives are acid-converted with cyanamide to an amidine salt starting from piperazine or its hydrate and then reacted with a dicarbonyl compound in the presence of a base to the end product.

REFERENCES:
patent: 4818756 (1989-04-01), Seidel et al.
patent: 4937343 (1990-06-01), Seidel et al.
patent: 4988809 (1991-01-01), Seidel et al.
D. J. Brown et al, The pyrimidines (1962), pp. 31-43.
D. J. Brown et al, The pyrimidines Supplement I (1970) pp. 20-24.
Hampton, Harris and Hauser, Organic Synthesis, vol. 47, (1967), pp. 92 to 96.

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