Process for the production of piperazinylpyrimidine derivatives

Details Process for the production of piperazinylpyrimidine derivatives Process for the production of piperazinylpyrimidine derivatives

1991-12-10

1993-04-06

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544402, C07D40304

Patent

active

052005208

ABSTRACT:
A process for the production of piperazinylpyrimidine derivatives of the formula I: ##STR1## wherein R.sub.1 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group, branched or unbranched. In the process, piperazine or its hydrate is acid-converted with cyanamide to an amidine salt and the latter is then reacted with a carbonyl compound in the presence of a base to the end product.

REFERENCES:
patent: 4818756 (1989-04-01), Seidel et al.
patent: 4937343 (1990-06-01), Seidel et al.
patent: 4988809 (1991-01-01), Seidel et al.
D. J. Brown et al., The pyrimidines (1962) pp. 31-43.
D. J. Brown et al., The pyrimidines Supplement I (1970) pp. 20-24.
Makin, S. M., et al., Zhurnal Organicheskoi Khimii, (1972), pp. 1415 to 1417.

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