Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process...
Patent
1990-09-25
1992-05-19
Doll, John
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
43524026, C12P 100, C12N 500
Patent
active
051148471
ABSTRACT:
A method for obtaining permanently culturable human and animal cell lines, as well as uses for these cell lines, are disclosed. The method involves fusing cells of a non-immortal cell line with cytoplasts or cytoplasma fractions of "immortal", transformed cells such as immortal myeloma cells, ascites-tumor cells or Epstein Barr Virus infected cells. Once fusion takes place the product is a permanently culturable variant of the previously normal cell line.
REFERENCES:
patent: 4172124 (1979-10-01), Koprowski et al.
patent: 4224404 (1980-09-01), Viza
patent: 4394448 (1983-07-01), Szoka, Jr. et al.
patent: 4464465 (1984-08-01), Lostrom
patent: 4465769 (1984-08-01), Hampar et al.
patent: 4537852 (1985-08-01), Sugimoto
Cassingena, et al., Transformation of Normal Diploid Cells by Isolated Metaphase Chromosomes of Virus-transformed . . . Gene, vol. 4, pp. 337-349, 1978.
Shay, et al., Nuclear Control of Tumorigenicity in Cells Reconstructed by PEG-Induced Fusion of Cell Fragments, J. Supramolecular Structure, vol. 11, pp. 33-49, 1979.
Howell, et al. Tumorigenicity and its Suppression in Cybrids of Mouse and Chinese Hamster Cell Lines, Proc. Natl. Acad. Sci. USA, vol. 75, No. 5 pp. 2358-2362, 1978.
Vedmett, et al., Reconstruction of Mammalian Cells from Nuclear and Cytoplasmic Components Separated by Treatment . . . , Proc. Natl. Acad. Sci. USA, vol. 71, No. 5, pp. 1999-2002, 1974.
Olsson, et al., Human-Human Hybridomas Producing Monoclonal Antibodies of Predefined Antigen Specificity, Proc. Natl. Acad. Sci. USA, vol. 77, No. 9, pp. 5429-5431, 1980.
Harris, H. et al., Feb. 13, 1965, Nature 205:640-646.
Bruno, J. et al., Dec. 1981, Mol. Cell. Biol. 1:1163-1176.
Jonak, Z. L., et al., Feb. 6, 1983, Hybridoma 2:124.
Hightower, J. H.,: 1982 in Techniques in Somantic Cell Genetics CL19, Plenum Press.
Prujansky-Jakobovits et al, "Alteration of Lymphocyte Surface Properties by Insertion of Foreign Functional Components", Proceedings of the National Academy of Sciences 77(12), pp. 7247-7251 (1980).
Veomett et al, "Reconstruction of Mammalian Cells from Nuclear and Cytoplasmic Components Separated by Treatment with . . . ", Proceedings of the National Academy of Sciences 71(5) pp. 1999-2002 (1974).
Kozbor et al, "Human Hybridomas Constructed with Antigen Specific EBV . . . ", Proceedings of the National Academy of Sciences 79 pp. 6651-6655 (1982).
Shih et al, "Passage of Phenotypes of Chemically Transformed Cells Via Transfection of DNA and Chromatin", Proceedings of the National Academy of Sciences 76(11) pp. 5714-5718 (1979).
Albert Winfried
Barchet Heinrich
Jungfer Herbert
Boehringer Mannheim GmbH
Doll John
Elliott George C.
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