Process for the production of pentostatin aglycone and...

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

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C536S027100, C536S027110, C536S027130

Reexamination Certificate

active

07393954

ABSTRACT:
A novel, scaleable and improved process for preparing pentostatin and its analogs is disclosed. The method comprises the diastereospecific synthesis of the nucleobase from commercially available L-Dialkyl tartarates.

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J. Org. Chem, Thien Van Truong et al, “Chirospecific Synthesis of the Tetrahydroimidazodiazepinol Aglycon of Pentostatin and Its Analogues”, 58, 6090-6096, 1993.
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Nucleosides & Nucleotides, Mikyung Hong, et al. “Irreversible, Tight-Binding Inhibition of Adenosine Deaminase By Coformycins: Inhibitor Structural Features That Contribute to the Mode of Enzyme Inhibition”, 16(7-9), 1053-1057, 1997.

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