Process for the production of penam and cephem derivatives

Details Process for the production of penam and cephem derivatives Process for the production of penam and cephem derivatives

1978-09-18

1980-05-13

Morgenstern, Norman

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

544 26, 544 23, 544 30, 2602452R, C07D49912, C07D50106

Patent

active

042028175

ABSTRACT:
A process for the preparation of penam and cephem derivatives by reacting a phosphite amide of a 6-aminopenicillanic acid or 7-aminocephalosporanic acid with an acyl halide in an aprotic solvent in the presence of a phosphite halide scavenger.

REFERENCES:
patent: 3994883 (1976-11-01), Borrevang et al.
Lucas et al., J. Am. Chem. Soc. vol. 72, pp. 5491-5497 (1950).
Chemical Abstracts, vol. 47, col. 10, 464(g) (1953). _

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