Process for the production of pancreatin pellets

Details Process for the production of pancreatin pellets Process for the production of pancreatin pellets

1979-10-31

1981-07-28

Czaja, Donald E.

Plastic and nonmetallic article shaping or treating: processes

Spheroidizing or rounding of solid particles

264141, B22D 1101

Patent

active

042809711

ABSTRACT:
Pancreatin pellets are produced by a process employing extrusion techniques. In the process, a mixture of pancreatin powder and selected solvent is formed into a pliable mass suitable for extrusion. The extrusion is conducted followed by a cutting, shaping or forming of the extruded mass into pre-pellet like forms. Further drying and mechanical working of the pre-pellet forms results in the final pancreatin pellet of improved pharmaceutical and mechanical stability. A special aspect of the process is the selection of a solvent for mixing with pancreatin powder that is harmless to enzymes. Such solvents typically include isopropanol and acetone.

REFERENCES:
patent: Re27214 (1971-11-01), Nakahara
patent: 3154603 (1964-10-01), Witheford et al.
patent: 3758679 (1973-09-01), Seidler

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