Process for the production of oxabispidines

Details Process for the production of oxabispidines Process for the production of oxabispidines

2005-08-30

2005-08-30

Saeed, Kamal A. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

Reexamination Certificate

active

06936712

ABSTRACT:
There is provided a process for the preparation of a compound of formula I, (I), or a pharmaceutically acceptable derivative thereof, wherein A, B, G, R1, R2, R3, R4and R41to R46have meanings given in the description, which process comprises the dehydrative cyclisaton of a compound of formula II, (II).

REFERENCES:
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patent: WO 91/07405 (1991-05-01), None
patent: WO 99/31100 (1999-06-01), None
patent: WO 01/18992 (2001-04-01), None
Paudler, et al; “1,5-Bis(p-toluenesulfonyl)-3,7-Dihydroxyoctahydro-1,5-diazocine”; J. Org. Chem. 31, 277-280 (1966).
Dave et al; “Facile Preparation of 3,7-Diazabicyclo[3.3.0]octane . . . 1,5-Diazacyclooctane 3,7-Derivatives1”; J. Org. Chem.; 61(25), 8897-8903 (1996).
Chapman et al; “Difluoramination of Heterocyclic Ketones: Control of Microbasicity”; J. Org. Chem. 63(5), 1566-1570 (1998).
Chapman et al; Nitrolysis of a Highly Deactivated Amide by Protonitronium. Synthesis and Structure of HNFX1; J. Org. Chem. 64(3), 960-965 (1999).
Paudler et al.; “3,7-Disubstituted Octahydro-1,5-diazocines. Their Conversion into . . . Ring-Contracted Products”; J. Org. Chem. 32, 2425-2430 (1967).
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