Process for the production of organ extracts with high herparin

Details Process for the production of organ extracts with high herparin Process for the production of organ extracts with high herparin

1980-03-19

1982-02-16

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated to proteinaceous toxin or fragment thereof

536 21, A61K 31725, C08B 3710

Patent

active

043159230

ABSTRACT:
A process for producing an aqueous solution of high heparin content from heparin-containing animal organs comprises forming a heparin-enriched granular raw material from these organs and extracting the raw material at a temperature of 20.degree. to 80.degree. C. with a salt solution having a salt concentration of 1.5 to 12.0% and a pH in the range of 8 to 12.8 or an alkalinity of 0.5 normal to 1.08 normal concentration. The dry substance to liquid ratio should be 1:5.

REFERENCES:
patent: 2571679 (1951-10-01), Butturini et al.
patent: 2989438 (1961-06-01), Nomine et al.
patent: 3865723 (1975-02-01), Marchisio et al.
patent: 4175182 (1979-11-01), Schmer

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