Process for the production of optically active 2-hydroxy acid es

Details Process for the production of optically active 2-hydroxy acid es Process for the production of optically active 2-hydroxy acid es

1993-10-22

1994-12-06

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435135, 435822, 435911, C12P 4100, C12P 762

Patent

active

053710142

ABSTRACT:
An optically active 2-hydroxy acid derivative is produced by treating a 2-oxo acid derivative with a microorganism, which has been optionally treated, capable of asymmetrically reducing said 2-oxo acid derivative into an optically active (R)- or (S)-2-hydroxy acid derivative represented by the formula (II) and recovering the optically active (R)- or (S)-hydroxy acid derivative thus formed. Optically active 2-hydroxy acid derivatives are important intermediates in the synthesis of various drugs such as a remedy for hypertension.

REFERENCES:
patent: 4609623 (1986-09-01), Leuchtenberger et al.
patent: 4785089 (1988-11-01), Blaser et al.
patent: 5098841 (1992-03-01), Ghisalba et al.
patent: 5256552 (1993-10-01), Matsuyama et al.
Deol et al., Aust. J. Chem., 29(11), pp. 2459-2467, 1976.
ATCC Catalogue of Fungi/Yeasts, 17th edition, pp. 324 and 346-347, 1987.

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