Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide
Patent
1984-01-20
1989-08-29
Goldberg, Jerome D.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using tissue cell culture to make a protein or polypeptide
435170, C12P 2102, C12P 104
Patent
active
048617156
ABSTRACT:
A process is disclosed for the fermentative production of the ergotropically effective antibiotic nourseothricin, with which, using different carbohydrate sources and suitable inorganic and organic nitrogen sources as well as different mineral salts, with or without addition of stock substances of the respiratory chain or the intracellular amino acid transport, and through influencing the phosphate substance exchange and avoidance of further limitations with regulated acidity conditions, high concentrations of this antibiotic are cultivated in the culture solution. The recovery of the active substance in the culture solution follows either by chromatographic techniques in the form of salts or through addition of a physiologically compatible adsorbent as mycelium-containing nourseothricin-adsorbate, which preferably can be added to the dosaging of mixed feed agents.
REFERENCES:
patent: 3965002 (1976-06-01), Magnusson
Martin and Demain, "Control of Antigiotic Brosynthesis"; Microbiological Reviews, vol. 44, No. 2, pp. 230-251 (1980).
Bergter Friedrich
Bocker Harald
Bormann Ernst-Joachim
Forberg Wolfgang
Fricke Heinz
Goldberg Jerome D.
Lipovsky Joseph A.
Striker Michael J.
VEB Jenapharm
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