Process for the production of new mutants of herpes simplex viru

Details Process for the production of new mutants of herpes simplex viru Process for the production of new mutants of herpes simplex viru

1981-06-08

1982-03-30

Rosen, Sam

Drug, bio-affecting and body treating compositions

Lymphokine

435237, 435238, A61K 3912, C12N 706

Patent

active

043224040

ABSTRACT:
Herpes virus was doubly mutated in two steps by treatment with phosphono formic acid and 5-ethyl-2'-desoxyuredine. In this way the pathogenicity of the herpes virus was so weakened that they are usable as vaccines.

REFERENCES:
patent: 4191745 (1980-04-01), Mayr et al.
Helgstrand et al.-Chem. Abst. vol. 92 (l980), p. 42112 t.
Schwoebel et al.-Chem. Abst. vol. 91 (1979), pp. 186, 482 r.
DeClercq et al.-Chem. Abst. vol. 89 (1978), p. 99707 h.
Eriksson, Antimicrobial Agents and Chematherapy, Jun. 1979, pp. 758-762.
Mayer et al., Virologische Arbeitsmelthoden, vol. 1, (1974), pp. 25-33 and 43-93.
Mauersberger Aktuelle Probleme der Zellzuchtung, 1971, pp. 17-60.

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