Process for the production of muconic acid

Details Process for the production of muconic acid Process for the production of muconic acid

1983-07-22

1988-03-15

Tarcza, John

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

435142, 4351721, 435877, C12N 120, C12N 1500, C12P 744, C12R 140

Patent

active

047313285

ABSTRACT:
This invention provides novel strains of microorganisms (e.g., Pseudomonas putida Biotype A) which are capable of converting substrates such as toluene or catechol to muconic acid quantitatively by the ortho (catechol 1,2-oxygenase) pathway.
Muconate lactonizing enzyme is not induced in the microorganism, thereby permitting the muconic acid to be produced and accumulated in a quantity greater than one gram of muconic acid per liter of bioconversion medium.

REFERENCES:
patent: 3383289 (1968-05-01), Raymond et al.
patent: 4355107 (1982-10-01), Maxwell
patent: 4480034 (1984-10-01), Hsieh
Condon et al., "Cold-Sensitive Mutation of Pseudomonas Putida Affecting Enzyme Synthesis at Low Temperature", Journal of Bacteriology, 94(6), pp. 1970-1981, (1967).
Tsuji et al., "Accumulation of Cis, Cis Muconic Acid from Benzoic Acid by a Mutant Induced from Corynebacterium Glutamicum", Hakko Kogaku Kaishi, 55(2), pp. 95-97, (1977), Chem. Abst. 86: 167646c.
Van der Linden et al., "Microbial Oxidation of Hydrocarbons", Advances in Enzymology, XXVII, pp. 506-516, (1965).
Gottschalk, "Bacterial Metabolism", Springer-Verlag, N.Y., 1979, pp. 126-131.
Ornston et al., "Isolation of Spontaneous Mutant Strains of Pseudomonas Putida", Biochemical and Biophysical Research Communications, 36(1), pp. 179-184, (1969).
Worsey et al., "Regulation of the Degradative Pathway Enzymes Coded for by the TOL Plasmid, (pWWO), from Pseudomonas Putida mt-2", Journal of Bacteriology, 134(3), pp. 757-764, (1978).
Worsey et al., "Characterization of a Spontaneously Occurring Mutant of the TOL20 Plasmid in Pseudomonas Putida MT20", Journal of Bacteriology, 130(3), pp. 1149-1158, (1977).

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