Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing oxygen-containing organic compound
Patent
1983-07-22
1986-05-13
Shapiro, Lionel M.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing oxygen-containing organic compound
435253, 4351721, 435877, 935 60, 935 83, 935 82, C12P 744, C12N 1500, C12N 116, C12R 140
Patent
active
045886881
ABSTRACT:
This invention provides a process for bioconversion of an organic substrate (e.g., ethylbenzene or catechol) to muconic acid.
This invention further provides a procedure for constructing novel strains of microorganisms (e.g., Pseudomonas putida Biotype A) which are capable of converting an organic substrate to muconic acid quantitatively by the ortho (catechol 1,2-oxygenase) pathway.
Muconate lactonizing enzyme is not induced in the microorganisms, thereby permitting the muconic acid to be produced and accumulated in a quantity greater than one gram of muconic acid per liter of growth medium.
REFERENCES:
patent: 3383289 (1968-05-01), Raymond et al.
patent: 4355107 (1982-10-01), Maxwell
patent: 4400468 (1983-08-01), Faber
Van der Linden et al., "Microbial Oxidation of Hydrocarbons", Advances in Enzymology 27, pp. 506-516 (1965).
Condon et al., "Cold Sensitive Mutation of Pseudomonas putida Affecting Enzyme Synthesis at Low Temperature", Journal of Bacteriology 94(6), pp. 1970-1981 (1967).
Tsuji et al., "Accumulation of Cis, Cis-Muconic Acid from Benzoic Acid by a Mutant Induced from Corynebacterium Glutamicum", Hakko Kogoku Kaishi 55(2), pp. 95-97 (1977) Chem. Abst. 86: 167-646.
Gottschalk, "Bacterial Metabolism", Springer-Verlag NY, pp. 126-131 (1979).
Ornston et al., "Isolation of Spontaneous Mutant Strains of Pseudomonas putida", Biochemical and Biophysical Research Communications 36(1), pp. 179-184 (1969).
Worsey et al., "Regulation of the Degradative Pathway Enzymes Coded for by the TOL Plasmid (pWWO) from Pseudomonas putida mt-2", Journal of Bacteriology 134(3), pp. 757-764 (1978).
Worsey et al., "Characterization of a Spontaneously Occurring Mutant of the TOL20 Plasmid in Pseudomonas putida MT20", Journal of Bacteriology 130(3), pp. 1149-1158 (1977).
Celanese Corporation
Shapiro Lionel M.
Tarcza John E.
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