Process for the production of modified proteins and product ther

Details Process for the production of modified proteins and product ther Process for the production of modified proteins and product ther

1983-11-14

1986-09-02

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an...

435177, 435178, 435180, 435181, 435188, 435183, 435196, 435233, 435234, 525 541, 530815, 530402, C12N 1114, C12N 1102, C12N 1110, C12N 1108, C12N 1106, C12N 996, C12N 900, C12N 916, C12N 990, C12N 992, C07K 308, C07K 1700

Patent

active

046096256

ABSTRACT:
A process is disclosed for chemically modifying naturally occurring proteins to produce enzyme-like modified proteins. The process comprises partially denaturing a cofactor containing holoprotein by removal of the cofactor to produce a partially denatured cofactorless or so-called apoprotein. The partially denatured protein is contacted with an inhibitor of a selected model enzyme and cross-linked. The resultant protein product is an enzyme-like modified protein having the catalytic characteristics of the model enzyme whose inhibitor is contacted with the partially denatured apoprotein.

REFERENCES:
patent: 4206286 (1980-06-01), Keyes
patent: 4366030 (1981-05-01), Tschang et al.
Yamauchi, et al., Reversible Conversion of Lysime Monooxygenase to an Oxidase; J. of Biol. Chem., vol. 248, 1973, pp. 3750-3752.
Mahler, et al., Biological Chemistry, 1966, Harper and Row, N.Y., pp. 287-295.
Beaven et al., International Journal of Peptide Research, vol. 5, pp. 215-218, 1973.

Affiliated with

Also associated with

Rating

Process for the production of modified proteins and product ther does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of modified proteins and product ther, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of modified proteins and product ther will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1097542