Process for the production of microcapsules

Details Process for the production of microcapsules Process for the production of microcapsules

1994-06-22

1997-07-15

Housel, James C.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424490, 424491, 424492, 424493, 424494, 424495, 424496, 424497, 424498, 424457, 424499, 424500, 424501, 424502, 430138, A61K 914, A61K 916, A61K 950

Patent

active

056480962

ABSTRACT:
A method for the production of microcapsules embedded with pharmaceuticals, peptides, proteins, enzymes and vaccines, which uses biodegradable solvents, and microcapsules free of toxic residual solvents is described. The microcapsules are obtained by spraying of a solution, suspension or water-in-oil dispersion of active materials and biodegradable polymers.

REFERENCES:
patent: 4637905 (1987-01-01), Gardner
patent: 5066436 (1991-11-01), Komen et al.
patent: 5354556 (1994-10-01), Sparks et al.
patent: 5366733 (1994-11-01), Brizzolara et al.
Derwent Abstract, Accession No. 85-1 30922, Kato 1985.
Nakano et al. Internation J. of Pharmaceutics 4: 291-298 (1980).
Japanese Abstract (see above).
Abstract, Derwent Publications Ltd., London, GB, AN 85-130922 & JP, A, 60 067 417 (KATOH) 17 Apr. 1985.
Bodmeier et al., Preparation of Biodegradable Poly.+-.lactide Microparticles Using a Spray-Drying Technique, J. Pharm. Pharmacol. 1988, 40:754-757.
Lewis, Controlled Release of Bioactive Agents from Lactide/Glycolide Polymers, Biodegradable Polymers as Drug Delivery Systems, pp. 1-41.
Spenlehauer et al., In Vitro and in Vivo degradation of Poly(D,L lactide/glycolide)Type Microspheres Made by Solvent Evaporation Method, Biomaterials, vol. 10, No. 8, Oct. 1989, pp. 557-563.
Wang et al., Degradation of poly(ester) microspheres, Biomaterials, vol. 11, No. 9, Nov. 1990, pp. 679-685.
Jailil et al., Biodegradable poly(lactic acid)and poly(lactide-co-glucolide) Microcapsules: Problems Associated with Preparative Techniques and Release Properties, J. Microencapsulation, 1990, vol. &, No. 3, pp. 297-325.

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