Process for the production of macrolide compounds

Details Process for the production of macrolide compounds Process for the production of macrolide compounds

1992-08-24

1995-01-03

Marx, Irene

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

4352535, 435244, 435 76, C12P 1718, C12N 120

Patent

active

053786173

ABSTRACT:
A process for the production of a compound of formula (I) ##STR1## which comprises cultivating a microorganism of the genus Streptomyces capable of producing the compound of formula (I) in the presence of one or more fatty acids and/or salts, esters and amides of these acids, whereby the compound of formula (I) is produced, and if desired isolating the said compound. The fatty acid increases the yield of the formula (I) compound and is preferably isobutyric or valeric acid.

REFERENCES:
patent: 4310519 (1982-01-01), Albers-Schonberg
Gullo et al., Abstr. Pap. Am Chem. Soc. 1983, (1986 Meet. MBTD28).
Stark et al., Antimicrob. Agents and Chemotherapy, 1967 pp. 353-358.

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