Process for the production of L-threonine by fermentation

Details Process for the production of L-threonine by fermentation Process for the production of L-threonine by fermentation

1989-01-23

1991-12-31

Robinson, Douglas W.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

4351721, 4352521, 435840, C12P 1308, C12N 1500, C12N 120

Patent

active

050772074

ABSTRACT:
A process for the production of L-threonine, comprising cultivating a mutant bacterial species belonging to the genus Brevibacterium from which dihydrodipicolinate synthase has been deleted or removed in a liquid medium; accumulating the L-threonine as a product of cultivation; and harvesting the L-threonine from the culture medium.

REFERENCES:
Stanbury et al., Principles of Fermentation Technology, 1984, pp. 40-42.
Goodfellow et al., "The Biology of the Actinomycetes", 1984, pp. 77-79.
Agric. Biol. Chem., vol. 43, No. 2, 1979, pp. 265-270; O. Tosaka et al.: "Mode of Conversion of asparto beta-semialdehyde to L-threonine and L-lysine in Brevibacterium lactofermentum".
Chemical Abstracts, vol. 93, 1980, p. 727, resume No. 6858t, Columbus, Ohio, U.S.; I. Murgov et al.: "Production of Br. flavum mutants Resistant to alpha-amino-beta-hydroxyvaleric Acid and Breeding of threonine Producers", & Nauchni Tr., Vissh Inst. Khranit. Vkusova Prom-St., Plovdiv 1978, 25, Pt. 2, 261-4.
Agric. Biol. Chem., vol. 42, No. 1, 1978, pp. 95-100; O. Tosaka et al.: "Pathway and regulation of lysine biosynthesis in Brevibacterium lactofermentum".
Biotechnology of Amino Acid Production, Progress in Industrial Microbiology, vol. 24, chapitre 15, 1986, pp. 173-182, Elsevier, Amsterdam, NL; S.
Nakamori: "Threonine and homoserine".

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