Process for the production of L-proline

Details Process for the production of L-proline Process for the production of L-proline

1982-09-16

1984-09-04

Brust, Joseph P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20712

Patent

active

044698763

ABSTRACT:
L-proline is produced from the methyl or ethyl ester of L-pyroglutamic acid by reacting this with at least twice the molar amount of phosgene to form the corresponding 1-chlorocarbonyl-5,5-dichloroproline ester, producing the corresponding 2-chloro-1-chlorocarbonyl-pyrrolin-(2)-carboxylic acid ester-(5) therefrom by splitting off hydrogen chloride, catalytically hydrogenating the pyrrolin-(2) compound to the corresponding N-chlorocarbonyl-proline ester and hydrolyzing the latter with acid to form L-proline.

REFERENCES:
patent: 3636043 (1972-01-01), Magerlein
Enders, et al., Chem. Bes. 112, pp. 3703--3714, (1979).
Monteiro, Synthesis, Communications, 1974, p. 137.

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