Process for the production of L-malic acid

Details Process for the production of L-malic acid Process for the production of L-malic acid

1985-09-20

1989-10-17

Richman, Barry S.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing oxygen-containing organic compound

2041823, 435136, 562580, 562582, 562593, 562595, C12P 746

Patent

active

048747009

ABSTRACT:
L-malic acid is separated by means of electrodialysis from reaction mixtures derived from biotechnical conversion of fumarate into L-malate. Fumaric acid present in the acid concentrate from the dialysis is separated from L-malic acid without precipitation reactions using stepwise crystallization. Crystallized L-malic acid is produced in high purity and large yield. The alkali concentrate obtained during electrodialysis is recycled back into the biotechnical conversion. The process operates without appreciable losses of valuable materials and is very economical.

REFERENCES:
patent: 3371112 (1968-02-01), Winstrom et al.
patent: 3391187 (1968-07-01), Cullen, Jr. et al.
patent: 3873425 (1975-03-01), Kobayashi et al.
patent: 3922195 (1975-11-01), Chibata et al.
patent: 3964985 (1976-06-01), Giuffrida
patent: 4486283 (1984-12-01), Tejeda
Desalination, 10 (1972) 157-180.

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