Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing nitrogen-containing organic compound
Patent
1989-05-09
1991-07-02
Lilling, Herbert J.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Preparing nitrogen-containing organic compound
4352528, 435280, C12R 119, C12P 1300
Patent
active
050285386
ABSTRACT:
The invention relates to a process for the L(-)-carnitine biochemical production, in an economically favorable way.
This new process is technically achievable with easily available raw, materials in simple reaction conditions and with not complicated substance separation techniques.
This process is carried out with bacteria that stereo-specifically hydrates crotonobetaine to L(-)-carnitine.
REFERENCES:
patent: 4650759 (1987-03-01), Yokozeki et al.
patent: 4708936 (1987-11-01), Kulla et al.
Chemical Abstracts, vol. 98, No. 15, abstract 122551z, Apr. 11, 1983; Seim et al., "Reductive Metabolism of L-carnitine . . . by Escherichia coli".
Chemical Abstracts, vol. 96, No. 21, abstract 177676h; May 24, 1982; Seim et al., "Formation of .gamma.-butyrobetain . . . by Proteus vulgaris".
Seim et al., "Stimulation of Anaerobic Growth of Salmonella typhanurium by Reduction of L-Carnitine, Carnitine Derivatives and Structure-Related Trimethylammonium Compounds"; Arch. Microbiol. 132: 91-95 (1982).
Seim et al., "Reduktiver Stoffwechsel des L-Carnitins und strakturverwandter Trimethylammonium verbindungen in Escherichia coli"; Acta Biol. Med. Germ., vol. 41, 11: 1009-1018 (1982).
Different Carnitine Acyltransferases in Calf Liver BBA 280, pp. 422-433 by Helge Erik Solberg.
Claus Rainer
Kleber Hans-Peter
Loester Heniz
Seim Hermann
Strack Erich
Lilling Herbert J.
Sigma Tau Industries Farmaceutiche Riunite S.p.A.
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