Process for the production of L-aspartyl-L-phenylalanine esters

Details Process for the production of L-aspartyl-L-phenylalanine esters Process for the production of L-aspartyl-L-phenylalanine esters

1985-03-04

1987-05-19

Warren, Charles F.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

435253, 435254, 435255, 435256, C12P 2102, C12N 120, C12N 114, C12N 118

Patent

active

046668381

ABSTRACT:
A process for producing L-aspartyl-L-phenylalanine alkyl or aryl esters wherein L-aspartic acid and L-phenylalanine which is esterified with an alkyl group having at least two carbon atoms, an aryl group or an aralkyl group, are contacted in an aqueous medium with particular microorganisms or enzyme fractions from these microorganisms and the condensed product crystallizes out due to insolubility in the aqueous medium.

REFERENCES:
patent: 4587214 (1986-05-01), Harada et al.
Snoke, "On the Mechanism of the Enzymatic Synthesis of Glutathione", J.A.C.S. 75 pp. 4872-4873 (1953).
Ito et al., "Enzymatic Synthesis of the Peptide in Bacterial Uridine Nucleotides", Journal of Biological Chemistry 237 (8), pp. 2689-2695 (1962).

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