Process for the production of L-amino acids using strains of...

Details Process for the production of L-amino acids using strains of... Process for the production of L-amino acids using strains of...

2002-09-26

2008-10-28

Mondesi, Robert B. (Department: 1656)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

Reexamination Certificate

active

07442530

ABSTRACT:
This invention relates to a process for the production of L-amino acids, in particular L-threonine, in which the following steps are performed: a) fermentation of microorganisms of the Enterobacteriaceae family which produce the desired L-amino acid, in which at least one or more of the genes, selected from the group iclR and fadR, or nucleotide sequences coding therefor, are enhanced, in particular overexpressed, b) accumulation of the desired L-amino acid in the medium or in the cells of the bacteria and c) isolation of the desired L-amino acid.

REFERENCES:
patent: 2003/0059903 (2003-03-01), Rieping et al.
patent: 1 408 123 (2004-04-01), None
Cortay et al (Regulation of the acetate operon inEscherichia coli: purification and functional characterization of the IclR repressor, The EMBO Journal vol. 10 No. 3 pp. 675-679, 1991).
Malumbers et al.(Molecular control Mechanism of lysine and threonine biosynthesis in amino acid-producing Corynebacteria: Redirecting carbon flow FEMS Microbiology Letters 143 (1996) 103-114).
Gui L et al: “Regulated expression of a repressor protein: FadR activates iclR.” Journal of Bacteriology. US, vol. 178, No. 15, Aug. 1996, pp. 4704-4709, XP002239530, ISSN: 0021-9193, the whole document.
Gui L et al: “Autoregulation of iclR, the gene encoding the repressor of the glyoxylate bypass operon.” Journal of Bacteriology. US, vol. 178, No. 1, Jan. 1996, pp. 321-324, XP002239531, ISSN: 0021-9193, the whole document.
Cortay J C et al: “Regulation of the acetate operon inEscherichia coli: purification and functional characterization of the IclR repressor.” The EMBO Journal. England, vol. 10, No. 3, Mar. 1991, pp. 675-679, XP002239532, ISSN: 0261-4189, cited in the application, the whole document.
Donald L J et al: “Mass spectrometric study of theEscherichia colirepressor proteins, IclR and GclR, and their complexes with DNA.” Protein Science: A Publication of the Protein Society. United States Jul. 2001, vol. 10, No. 7, Jul. 2001, pp. 1370-1380, XP008016713, ISSN: 0961-8368, the whole document.
Xu Y et al: “The FadR.DNA complex. Transcriptional control of fatty acid metabolism inEscherichia coli.” The Journal of Biological Chemistry. US, vol. 276, No. 20, May 18, 2001 pp. 17373-17379, XP002247351, ISSN: 0021-9258, the whole document.
Farmer W R et al: “Reduction of aerobic acetate production byEscherichia coli.” Applied and Environmental Microbiology. US, vol. 63, No. 8, Aug. 1997, pp. 3205-3210, XP002247352, ISSN:0099-2240, the whole document.
Dirusso C C et al: “Fatty acyl-coA binding domain of the transcription factor FadR. Characterization by deletion, affinity labeling, and isothermal titration calorimetry.” The Journal of Biological Chemistry. US, vol. 273, No. 50, Dec. 11, 1998, pp. 33652-33659, XP002247353, ISSN: 0021-9258, the whole document.
Landgraf J R et al: “The Role of H-NS in One Carbon Metabolism” Biochimie, Masson, Paris, FR, vol. 76, No. 10/11, 1994, pp. 1063-1070, XP008014239, ISSN: 0300-9084, the whole document.

Affiliated with

Also associated with

Rating

Process for the production of L-amino acids using strains of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the production of L-amino acids using strains of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the production of L-amino acids using strains of... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4004458