Process for the production of L-amino acids by fermentation...

Details Process for the production of L-amino acids by fermentation... Process for the production of L-amino acids by fermentation...

2006-12-05

2006-12-05

Prouty, Rebecca E. (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S320100, C435S252800, C435S476000, C435S252320, C435S252330, C536S063000

Reexamination Certificate

active

07144724

ABSTRACT:
A process for the production of an L-amino acid wherein coryneform bacteria (e.g.Coryneform glutamicum) in which expression of the mqo gene coding for malate quinone oxidoreductase is attenuated are fermented to produce a desired amino acid, and the amino acid is concentrated in the medium or cells and isolated. Optionally, further genes in the biosynthetic pathway of the desired amino acid are enhanced, and/or metabolic pathways that reduce formation of the amino acid are suppressed.

REFERENCES:
patent: 1 038 969 (2000-09-01), None
patent: 1 085 091 (2001-03-01), None
Molenaar et al., Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) from Corynebacterium glutamicum. Eur. J. Biochem. 254: 395-403, 1998.
Douwe Molenaar et al., “Functions of the Membrane-Associated and Cytoplasmic Malate Dehydrogenases in the Citric Acid Cycle ofCorynebacterium glutamicum”, XP-002182880, vol. 182, No. 24, pp. 6884-6891, Dec. 2000 J. Bacteriol.
Michel E. van der Rest et al., “Functions of the Membrane-Associated and Cytoplasmic Malate Dehydrogenases in the Citric Acid Cycle ofEscherichia coli”, XP-002179953, vol. 182, No. 24, pp. 6892-6899, Dec. 2000 J. Bacteriol.
Douwe Molenaar et al., “Biochemical and genetic characterization of the membrane-associated malate dehydrogenase (acceptor) fromCorynebacterium glutamicum”, XP-000941422, vol. 254, pp. 395-403, Jan. 1998 Eur. J. Biochem.

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