Process for the production of insulin by genetically transformed

Details Process for the production of insulin by genetically transformed Process for the production of insulin by genetically transformed

1976-04-23

1978-04-04

Tanenholtz, Alvin E.

Textiles: fiber preparation

195 1, 195 80R, 195 18, 195 81, C12D 1302

Patent

active

040826139

ABSTRACT:
A process for the production of insulin using fungal cells. Human insulin producing cells are extracted to obtain the functional genome (the genetic material which determines the capacity of the cells to produce insulin) which is used to transform fungal cells, making them capable of producing insulin. The insulin has been extracted and identified by radioimmune assay and by bioassay. The same process can also be applied to produce animal insulins using specific specie transforming functional insulinogenic genomes. A process for serial secondary culture of insulin producing cells is disclosed. The significance of the invention is related to the great need to produce human insulin in large amounts. Human insulin has distinct biological and clinical advantages when compared with commercially available animal insulins now used for the treatment of diabetes mellitus in man.

REFERENCES:
vanek et al., Genetics of Industrial Microorganisms, vol. II, p. 38, Elsevier Pub. Co., 1973.
Willmer, Cells and Tissues in Culture, vol. 2, p. 674, Academic Press, 1965.

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